Lrrc8a^em1Uia
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrrc8a^em1Uia
• Name: leucine rich repeat containing 8A VRAC subunit A; endonuclease-mediated mutation 1, University of Iowa
• MGI ID: MGI:6467352
• Synonyms: SWELL1^fl
• Gene: Lrrc8a Location: Chr2:30127781-30153802 bp, + strand Genetic Position: Chr2, 21.41 cM
• Alliance: Lrrc8a^em1Uia page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed exon 3. (J:246515)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrc8a Mutation: 54 strains or lines available

References

• Original: J:246515 Zhang Y, et al., SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 May;19(5):504-517
• All: 10 reference(s)