Pqbp1^tm1.1Hiok
Targeted Allele Detail

Summary

• Symbol: Pqbp1^tm1.1Hiok
• Name: polyglutamine binding protein 1; targeted mutation 1.1, Hitoshi Okazawa
• MGI ID: MGI:6467464
• Gene: Pqbp1 Location: ChrX:7760759-7765469 bp, - strand Genetic Position: ChrX, 3.56 cM
• Alliance: Pqbp1^tm1.1Hiok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279053
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 3 to 7 were flanked by loxP sites and an FRT site flanked neomycin selection cassette. The neo cassette was removed by crossing with CAG-FLPe recombinase transgenic mice. (J:279053)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pqbp1 Mutation: 4 strains or lines available

References

• Original: J:279053 Ito H, et al., In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells. Mol Psychiatry. 2015 Apr;20(4):459-71
• All: 4 reference(s)