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Styk1tm1Twa
Targeted Allele Detail
Summary
Symbol: Styk1tm1Twa
Name: serine/threonine/tyrosine kinase 1; targeted mutation 1, Thierry Walzer
MGI ID: MGI:6467474
Synonyms: Styk1EGFP
Gene: Styk1  Location: Chr6:131276096-131330532 bp, - strand  Genetic Position: Chr6, 63.44 cM
Alliance: Styk1tm1Twa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:277150
Parent Cell Line:  JM8A3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsEUCOMM vector PRPGS00082_B_F08 was modified to replace the lacZ gene with an EGFP cassette in the exon 2. It also contains the frt and LoxP sites that allow Cre-mediated conditional targeting of the gene following Flp-mediated recombination to remove the reporter gene. RT-QPCR analysis confirmed the absence of mRNA expression in NK cells from homozygous mutant mice. (J:277150)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
 
 
Phenotypes:
Affected Systems
show or hide all annotated terms
   
immune system
N N
immune system phenotype
N N
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Styk1 Mutation:  31 strains or lines available
References
Original:  J:277150 Fauteux S, et al., Styk1 expression is a hallmark of murine NK cells and other NK1.1(+) subsets but is dispensable for NK-cell development and effector functions. Eur J Immunol. 2019 May;49(5):677-685
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory