Vps13b^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Vps13b^tm1.2Ics
• Name: vacuolar protein sorting 13B; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:6467991
• Synonyms: Vps13b^deltaEx3
• Gene: Vps13b Location: Chr15:35371306-35931375 bp, + strand Genetic Position: Chr15, 14.46 cM, cytoband B3.3
• Alliance: Vps13b^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296169
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 3. The neo cassette was removed through subsequent flp-mediated recombination. Exon 3 was deleted through subsequent cre-mediated recombination, creating a frameshift in the reading frame. (J:296169)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vps13b Mutation: 216 strains or lines available

References

• Original: J:296169 Da Costa R, et al., Vps13b is required for acrosome biogenesis through functions in Golgi dynamic and membrane trafficking. Cell Mol Life Sci. 2020 Feb;77(3):511-529
• All: 3 reference(s)