Relnem1Mhat
Endonuclease-mediated Allele Detail
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Symbol: |
Relnem1Mhat |
Name: |
reelin; endonuclease-mediated mutation 1, Mitsuharu Hattori |
MGI ID: |
MGI:6468501 |
Synonyms: |
PA-DV KI, RelnPA-DV |
Gene: |
Reln Location: Chr5:22089452-22549700 bp, - strand Genetic Position: Chr5, 9.98 cM, cytoband A3-B1
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Alliance: |
Relnem1Mhat page
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Allele Type: |
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Endonuclease-mediated (Not Applicable) |
Mutation: |
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Nucleotide substitutions
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Mutation details: CRISPR/Cas9 technology generated a CC to GA change resulting in a proline to aspartate substitution at amino acid 1244 (P1244D) as well as a C to T change resulting in an alanine to valine substitution at amino acid 1245 (A1245V). These mutations abolish the key cleavage site and make the protein uncleavable by ADAMTS-3.
(J:293055)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Reln Mutation: |
209 strains or lines available
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Original: |
J:293055 Okugawa E, et al., Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice. Sci Rep. 2020 Mar 11;10(1):4471 |
All: |
2 reference(s) |
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