About   Help   FAQ
Relnem1Mhat
Endonuclease-mediated Allele Detail
Summary
Symbol: Relnem1Mhat
Name: reelin; endonuclease-mediated mutation 1, Mitsuharu Hattori
MGI ID: MGI:6468501
Synonyms: PA-DV KI, RelnPA-DV
Gene: Reln  Location: Chr5:22089452-22549700 bp, - strand  Genetic Position: Chr5, 9.98 cM, cytoband A3-B1
Alliance: Relnem1Mhat page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Not Applicable)
Mutation:    Nucleotide substitutions
 
Mutation detailsCRISPR/Cas9 technology generated a CC to GA change resulting in a proline to aspartate substitution at amino acid 1244 (P1244D) as well as a C to T change resulting in an alanine to valine substitution at amino acid 1245 (A1245V). These mutations abolish the key cleavage site and make the protein uncleavable by ADAMTS-3. (J:293055)
Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Reln Mutation:  209 strains or lines available
References
Original:  J:293055 Okugawa E, et al., Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice. Sci Rep. 2020 Mar 11;10(1):4471
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/05/2024
MGI 6.24
The Jackson Laboratory