Zbed3^tm1.1Lil
Targeted Allele Detail

Summary

• Symbol: Zbed3^tm1.1Lil
• Name: zinc finger, BED type containing 3; targeted mutation 1.1, Lei Li
• MGI ID: MGI:6469491
• Synonyms: Zbed3^delta
• Gene: Zbed3 Location: Chr13:95460120-95474349 bp, + strand Genetic Position: Chr13, 49.38 cM
• Alliance: Zbed3^tm1.1Lil page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296111
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Using a targeting vector from the International Knockout Mouse Consortium (IKMC), the following elements were inserted: an FRT site, a lacZ beta-galactosidase reporter gene cassette (En2 splice acceptor, IRES, lacZ gene, poly(A) signal sequence), a loxP site, a neomycin resistance gene cassette, a second FRT site, and a second loxP site into intron 1 and a third loxP site into intron 2. The floxed exon 2 was deleted through subsequent cre-mediated recombination by crossing mice carrying this allele with mice carrying a Zp3-Cre allele. (J:296111)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbed3 Mutation: 16 strains or lines available

References

• Original: J:296111 Gao Z, et al., Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles. J Mol Cell Biol. 2018 Feb 1;10(1):74-88
• All: 1 reference(s)