Slc25a11^em1Syki
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc25a11^em1Syki
• Name: solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11; endonuclease-mediated mutation 1, Soo-Youl Kim
• MGI ID: MGI:6469639
• Synonyms: SLC25A11^-
• Gene: Slc25a11 Location: Chr11:70535022-70538305 bp, - strand Genetic Position: Chr11, 43.21 cM
• Alliance: Slc25a11^em1Syki page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was targeted with two sgRNAs (5-ACTGCATCCGGTTCTTCACC-3, 5-CGGATGCAGTTGAGTGGTGA-3) using CRISPR/Cas9 technology, resulting in a 7 bp (TGAAGGG) deletion. (J:294965)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc25a11 Mutation: 22 strains or lines available

References

• Original: J:294965 Lee JS, et al., Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation. EBioMedicine. 2019 Feb;40:184-197
• All: 1 reference(s)