Opcml^tm1.1Pagr
Targeted Allele Detail

Summary

• Symbol: Opcml^tm1.1Pagr
• Name: opioid binding protein/cell adhesion molecule-like; targeted mutation 1.1, Paul Grossfeld
• MGI ID: MGI:6469751
• Synonyms: OPCML^neo
• Gene: Opcml Location: Chr9:27702071-28836706 bp, + strand Genetic Position: Chr9, 13.73 cM
• Alliance: Opcml^tm1.1Pagr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294154
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1 and a second loxP site plus an FRT site flanked neomycin resistance gene into intron 2. Exon 2 was deleted through subsequent cre-mediated recombination. Northern blot analysis of brain RNA confirmed absence of transcript expression from this allele. (J:294154)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Opcml Mutation: 31 strains or lines available

References

• Original: J:294154 Ye M, et al., Gene-targeted deletion of OPCML and Neurotrimin in mice does not yield congenital heart defects. Am J Med Genet A. 2014 Apr;164A(4):966-74
• All: 2 reference(s)