Rtp4em#Xzs
Endonuclease-mediated Allele Detail
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Symbol: |
Rtp4em#Xzs |
Name: |
receptor transporter protein 4; endonuclease-mediated mutation, Xin-zhuan Su |
MGI ID: |
MGI:6470099 |
Synonyms: |
Rtp4- |
Gene: |
Rtp4 Location: Chr16:23339041-23432972 bp, + strand Genetic Position: Chr16, 14.55 cM, cytoband B1
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Alliance: |
Rtp4em#Xzs page
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Allele Type: |
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Endonuclease-mediated (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: The first and second coding exons (1 and 2) were targeted with two sgRNAs (5-ccccgatgacttcagtacttggg-3 and 5- cctcagacccggaatacggatttt-3) using CRISPR/Cas9 technology. Five founder mice were created with at least two different size deletions, both including the end of exon 1, intron 1 and the start of exon 2. The pound # sign is used in the allele symbol because which mouse line was used, or if a mixture was used, is not specified.
(J:293929)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rtp4 Mutation: |
19 strains or lines available
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Original: |
J:293929 He X, et al., RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology. Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19465-19474 |
All: |
1 reference(s) |
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