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Rtp4em#Xzs
Endonuclease-mediated Allele Detail
Summary
Symbol: Rtp4em#Xzs
Name: receptor transporter protein 4; endonuclease-mediated mutation, Xin-zhuan Su
MGI ID: MGI:6470099
Synonyms: Rtp4-
Gene: Rtp4  Location: Chr16:23339041-23432972 bp, + strand  Genetic Position: Chr16, 14.55 cM, cytoband B1
Alliance: Rtp4em#Xzs page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe first and second coding exons (1 and 2) were targeted with two sgRNAs (5-ccccgatgacttcagtacttggg-3 and 5- cctcagacccggaatacggatttt-3) using CRISPR/Cas9 technology. Five founder mice were created with at least two different size deletions, both including the end of exon 1, intron 1 and the start of exon 2. The pound # sign is used in the allele symbol because which mouse line was used, or if a mixture was used, is not specified. (J:293929)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rtp4 Mutation:  19 strains or lines available
References
Original:  J:293929 He X, et al., RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology. Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19465-19474
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory