Tg(Nphs1-ACE2)#Kdbu
Transgene Detail

Summary

• Symbol: Tg(Nphs1-ACE2)#Kdbu
• Name: transgene insertion, Kevin D Burns
• MGI ID: MGI:6470404
• Transgene: Tg(Nphs1-ACE2)#Kdbu Location: unknown
• Alliance: Tg(Nphs1-ACE2)#Kdbu page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Nphs1-ACE2)#Kdbu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACE2 (59272)

  Ace2	(MGI:1917258)

• Mutation details: The human ACE2 cDNA with a double hemagglutinin epitope tag at the 5' end is under the control of the murine nephrin promoter. Real-time RT-PCR detected mRNA in glomeruli at a level approximately 50-fold higher than in kidney cortex. Although only one line was analyzed, the pound symbol (#) is used because the line is not specified. (J:198181)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:198181 Nadarajah R, et al., Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice. Kidney Int. 2012 Aug;82(3):292-303
• All: 1 reference(s)