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Gt(ROSA)26Sorem1(CAG-Zfas1)Cya
Endonuclease-mediated Allele Detail
Summary
Symbol: Gt(ROSA)26Sorem1(CAG-Zfas1)Cya
Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Cyagen Biosciences
MGI ID: MGI:6470593
Synonyms: Gt(ROSA)26Sorem1(CAG-Zfas1)Cgen, ZFAS1 TG
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sorem1(CAG-Zfas1)Cya page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sorem1(CAG-Zfas1)Cya expresses 1 gene
 
Mutation detailsThe following cassette was inserted into intron 1 using a gRNA with CRISPR/Cas9 technology: the CAG promoter, a loxP site flanked STOP cassette, the mouse Zfas1 gene, and poly(A) signal sequence. This creates a conditional-ready allele that will only express Zfas1 after cre-mediated removal of the floxed STOP cassette. (J:294533)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  992 strains or lines available
References
Original:  J:294533 Jiao L, et al., lncRNA-ZFAS1 induces mitochondria-mediated apoptosis by causing cytosolic Ca(2+) overload in myocardial infarction mice model. Cell Death Dis. 2019 Dec 9;10(12):942
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory