Gt(ROSA)26Sorem1(CAG-Zfas1)Cya
Endonuclease-mediated Allele Detail
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Symbol: |
Gt(ROSA)26Sorem1(CAG-Zfas1)Cya |
Name: |
gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Cyagen Biosciences |
MGI ID: |
MGI:6470593 |
Synonyms: |
Gt(ROSA)26Sorem1(CAG-Zfas1)Cgen, ZFAS1 TG |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sorem1(CAG-Zfas1)Cya page
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Allele Type: |
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Endonuclease-mediated (Conditional ready, Inserted expressed sequence) |
Mutation: |
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Insertion
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Gt(ROSA)26Sorem1(CAG-Zfas1)Cya expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
mouse |
Zfas1 (MGI:1916199) |
floxed STOP cassette between CAG promoter and Zfas1 gene |
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Mutation details: The following cassette was inserted into intron 1 using a gRNA with CRISPR/Cas9 technology: the CAG promoter, a loxP site flanked STOP cassette, the mouse Zfas1 gene, and poly(A) signal sequence. This creates a conditional-ready allele that will only express Zfas1 after cre-mediated removal of the floxed STOP cassette.
(J:294533)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
993 strains or lines available
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Original: |
J:294533 Jiao L, et al., lncRNA-ZFAS1 induces mitochondria-mediated apoptosis by causing cytosolic Ca(2+) overload in myocardial infarction mice model. Cell Death Dis. 2019 Dec 9;10(12):942 |
All: |
1 reference(s) |
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