Pcgf1^tm1.1Hko
Targeted Allele Detail

Summary

• Symbol: Pcgf1^tm1.1Hko
• Name: polycomb group ring finger 1; targeted mutation 1.1, Haruhiko Koseki
• MGI ID: MGI:6470899
• Synonyms: Pcgf1^fl
• Gene: Pcgf1 Location: Chr6:83054850-83057836 bp, + strand Genetic Position: Chr6, 35.94 cM
• Alliance: Pcgf1^tm1.1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243420
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2 through 7 were floxed. Flp-mediated recombination removed the selection cassette inserted downstream of exon 7. (J:243420)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pcgf1 Mutation: 21 strains or lines available

References

• Original: J:243420 Almeida M, et al., PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation. Science. 2017 Jun 09;356(6342):1081-1084
• All: 9 reference(s)