Flt3^em1Akp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Flt3^em1Akp
• Name: FMS-like tyrosine kinase 3; endonuclease-mediated mutation 1, Karolina Palucka
• MGI ID: MGI:6470929
• Gene: Flt3 Location: Chr5:147267551-147337299 bp, - strand Genetic Position: Chr5, 86.88 cM, cytoband G3
• Alliance: Flt3^em1Akp page

Mutation origin

• Strain of Origin: NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing is used to delete a 436 bp region that incorporate exon 3 and leads to exon 3 skipping and the production of a nonfunctional mRNA. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Flt3 Mutation: 85 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 2 reference(s)