Gt(ROSA)26Sor^{tm1(CAG-Dmrt1,-EGFP)Zark}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Dmrt1,-EGFP)Zark}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David Zarkower
• MGI ID: MGI:6471079
• Synonyms: CAG-Stop-Dmrt1-Gfp
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Dmrt1,-EGFP)Zark} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247636
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Dmrt1,-EGFP)Zark} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Dmrt1 (MGI:1354733)

• Mutation details: The targeting vector contains a CAG promoter followed by a loxP-STOP-loxP (containing a Pgk-Neo in reverse orientation), human beta-globin (HBB) 5'; UTR, mouse Dmrt1 coding sequence, an FRT-flanked IRES-EGFP and a triple polyA inserted downstream of exon of the ROSA26 locus. (J:247636)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1040 strains or lines available

References

• Original: J:247636 Lindeman RE, et al., Sexual cell-fate reprogramming in the ovary by DMRT1. Curr Biol. 2015 Mar 16;25(6):764-71
• All: 1 reference(s)