Slc16a3^tm1.1Lupel
Targeted Allele Detail

Summary

• Symbol: Slc16a3^tm1.1Lupel
• Name: solute carrier family 16 (monocarboxylic acid transporters), member 3; targeted mutation 1.1, Luc Pellerin
• MGI ID: MGI:6471733
• Synonyms: MCT4^f, MCT4^fE3-5
• Gene: Slc16a3 Location: Chr11:120839310-120849826 bp, + strand Genetic Position: Chr11, 84.73 cM
• Alliance: Slc16a3^tm1.1Lupel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296658
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 5. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 3-5 floxed. (J:296658)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc16a3 Mutation: 25 strains or lines available

References

• Original: J:296658 Boucanova F, et al., Disrupted function of lactate transporter MCT1, but not MCT4, in Schwann cells affects the maintenance of motor end-plate innervation. Glia. 2020 Jul 20
• All: 4 reference(s)