Hnrnpa2b1^tm1.1Caox
Targeted Allele Detail

Summary

• Symbol: Hnrnpa2b1^tm1.1Caox
• Name: heterogeneous nuclear ribonucleoprotein A2/B1; targeted mutation 1.1, Xuetao Cao
• MGI ID: MGI:6471775
• Synonyms: Hnrnpa2b1^fl
• Gene: Hnrnpa2b1 Location: Chr6:51437912-51446874 bp, - strand Genetic Position: Chr6, 24.87 cM, cytoband B3
• Alliance: Hnrnpa2b1^tm1.1Caox page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283622
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2 to 6 were flanked by loxP sites. A FRT-flanked PGK-neo cassette was inserted upstream of the floxed exons. Flp-mediated recombination removed the selection cassette, leaving exons 2-6 floxed. (J:283622)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hnrnpa2b1 Mutation: 47 strains or lines available

References

• Original: J:283622 Wang L, et al., Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses. Science. 2019 Aug 16;365(6454)
• All: 1 reference(s)