Pgap4^em1Osbir
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pgap4^em1Osbir
• Name: post-GPI attachment to proteins GalNAc transferase 4; endonuclease-mediated mutation 1, Taroh Kinoshita
• MGI ID: MGI:6471949
• Synonyms: Pgap4^-, PGAP4-KO, Tmem246^{em1(EGFP)Osbir}
• Gene: Pgap4 Location: Chr4:49584506-49597876 bp, - strand Genetic Position: Chr4, 26.63 cM
• Alliance: Pgap4^em1Osbir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104881
• Parent Cell Line: EGR-G101 (ES Cell)
• Strain of Origin: C57BL/6NSlc-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Endonuclease-mediated (Reporter)
• Mutation: Insertion
• Mutation details: An EGFP reporter gene was placed 45 bp downstream of the translation initiation codon. Mass spectrometry analysis confirmed loss of the GalNAc side chain in cellular prion protein (PrP^C) glycosylphosphatidylinositol (GPI) in homozygous mutant brains. (J:104881, J:333707)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pgap4 Mutation: 15 strains or lines available

References

• Original: J:104881 The RIKEN BioResource Center, Information obtained from The RIKEN BioResource Center. Unpublished. 2006-2013
• All: 2 reference(s)