Galnt11^tm1Kgth
Targeted Allele Detail

Summary

• Symbol: Galnt11^tm1Kgth
• Name: polypeptide N-acetylgalactosaminyltransferase 11; targeted mutation 1, Kelly G Ten Hagen
• MGI ID: MGI:6472727
• Gene: Galnt11 Location: Chr5:25427732-25470916 bp, + strand Genetic Position: Chr5, 12.35 cM
• Alliance: Galnt11^tm1Kgth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287843
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6, encoding a highly conserved region of the catalytic domain, was replaced with a neomycin selection cassette. (J:287843)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Galnt11 Mutation: 28 strains or lines available

References

• Original: J:287843 Tian E, et al., Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25196-25202
• All: 1 reference(s)