Jpx^em1Ehea
Endonuclease-mediated Allele Detail

Summary

• Symbol: Jpx^em1Ehea
• Name: Jpx transcript, Xist activator (non-protein coding); endonuclease-mediated mutation 1, Edith Heard
• MGI ID: MGI:6473336
• Synonyms: deltaJpx
• Gene: Jpx Location: ChrX:102537164-102550031 bp, + strand Genetic Position: ChrX, 46.17 cM
• Alliance: Jpx^em1Ehea page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The locus was deleted using sgRNAs (GGTCACAATTATGCAACCTG, ATACTCCGGATTACATACTC, TGCCCAAGCAAAAAGCGTGA, AGTTAGATACCACACCAAGT) with CRISPR/Cas9 technology. (J:293830)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jpx Mutation: 2 strains or lines available

References

• Original: J:293830 Collombet S, et al., Parental-to-embryo switch of chromosome organization in early embryogenesis. Nature. 2020 Apr;580(7801):142-146
• All: 1 reference(s)