Gt(ROSA)26Sor^{tm1(CAG-SNCA)Tanj}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-SNCA)Tanj}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Kunikazu Tanji
• MGI ID: MGI:6473659
• Synonyms: Syn-flox
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-SNCA)Tanj} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283567
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-SNCA)Tanj} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: The targeting construct inserted into the locus a CAG promoter, a loxP-flanked STOP cassette with 3 SV40 polyadenylation sequences and the human alpha-synuclein cDNA, woodchuck hepatitis virus posttrascriptional regulatory element (WPRE), and bGH polyl(A). Expression of the gene can only be achieved by cre-mediated removal of the floxed neo STOP cassette. (J:283567)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:283567 Tanji K, et al., A mouse model of adult-onset multiple system atrophy. Neurobiol Dis. 2019 Jul;127:339-349
• All: 1 reference(s)