Vwf^tm1.1Vhf
Targeted Allele Detail

Summary

• Symbol: Vwf^tm1.1Vhf
• Name: Von Willebrand factor; targeted mutation 1.1, Veronica H Flood
• MGI ID: MGI:6473963
• Synonyms: 1399H
• Gene: Vwf Location: Chr6:125529911-125663642 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Vwf^tm1.1Vhf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:295694
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Exon 28 was replaced with one containing an arginine to histidine substitution at amino acid 1399 (p.R1399H) and a loxP-flanked neomycin resistance cassette was introduced downstream of exon 28. The selection cassette was removed via cre-mediated recombination. (J:295694)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vwf Mutation: 140 strains or lines available

References

• Original: J:295694 Slobodianuk TL, et al., Defective collagen binding and increased bleeding in a murine model of von Willebrand disease affecting collagen IV binding. J Thromb Haemost. 2019 Jan;17(1):63-71
• All: 1 reference(s)