Spry1^tm1Mns
Targeted Allele Detail

Summary

• Symbol: Spry1^tm1Mns
• Name: sprouty RTK signaling antagonist 1; targeted mutation 1, Mario Encinas
• MGI ID: MGI:6474241
• Synonyms: Spry1^Y53ANeo
• Gene: Spry1 Location: Chr3:37694096-37698747 bp, + strand Genetic Position: Chr3, 18.46 cM
• Alliance: Spry1^tm1Mns page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294660
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Nucleotide substitutions in the open reading frame TAC to GGC produced the amino acid substitution of tyrosine with alanine at position 53 (Y53A). An FRT-flanked neomycin resistance cassette was inserted downstream of the modified coding region. (J:294660)

Expression

In Mice Carrying this Mutation:

36 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spry1 Mutation: 16 strains or lines available

References

• Original: J:294660 Vaquero M, et al., Sprouty1 Controls Genitourinary Development via its N-Terminal Tyrosine. J Am Soc Nephrol. 2019 Aug;30(8):1398-1411
• All: 1 reference(s)