Mink1^tm1.2Lgrl
Targeted Allele Detail

Summary

• Symbol: Mink1^tm1.2Lgrl
• Name: misshapen-like kinase 1 (zebrafish); targeted mutation 1.2, Linrong Lu
• MGI ID: MGI:6474250
• Gene: Mink1 Location: Chr11:70453707-70505309 bp, + strand Genetic Position: Chr11, 43.0 cM, cytoband B4
• Alliance: Mink1^tm1.2Lgrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231551
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream on exon 3 and an FRT and loxP flanked neo cassette was inserted downstream of exon 4. Flp and cre mediated recombination removed the neo cassette and exons 3 and 4. (J:231551)

Expression

In Mice Carrying this Mutation:

11 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mink1 Mutation: 85 strains or lines available

References

• Original: J:231551 Yue M, et al., Misshapen/NIK-related kinase (MINK1) is involved in platelet function, hemostasis, and thrombus formation. Blood. 2016 Feb 18;127(7):927-37
• All: 3 reference(s)