Ndufab1^tm1Xiwa
Targeted Allele Detail

Summary

• Symbol: Ndufab1^tm1Xiwa
• Name: NADH:ubiquinone oxidoreductase subunit AB1; targeted mutation 1, Xianhua Wang
• MGI ID: MGI:6476764
• Synonyms: Ndufab1^f
• Gene: Ndufab1 Location: Chr7:121686038-121701071 bp, - strand Genetic Position: Chr7, 65.38 cM
• Alliance: Ndufab1^tm1Xiwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:293657
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 2 and a second loxP site and an FRT site flanked neomycin resistance gene cassette into intron 3, creating a conditional-ready allele with exon 3 floxed. (J:293657)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndufab1 Mutation: 8 strains or lines available

References

• Original: J:293657 Zhang R, et al., NDUFAB1 protects against obesity and insulin resistance by enhancing mitochondrial metabolism. FASEB J. 2019 Dec;33(12):13310-13322
• All: 1 reference(s)