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Ttll7tm1Seto
Targeted Allele Detail
Summary
Symbol: Ttll7tm1Seto
Name: tubulin tyrosine ligase-like family, member 7; targeted mutation 1, Mitsutoshi Setou
MGI ID: MGI:6476783
Synonyms: 7KO
Gene: Ttll7  Location: Chr3:146558122-146689764 bp, + strand  Genetic Position: Chr3, 72.28 cM, cytoband H3
Alliance: Ttll7tm1Seto page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:345300
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3 were replaced with a neo cassette. Exons 2 and 3 include initiation codons. ATGs were removed by homologous recombination. Immunoblot analysis with anti-TTLL7 antibodies confirmed the absence of protein expression in brain lysates from homozygous mutant mice. (J:345300)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
 
involves: 129 * 129S/SvEv * C57BL/6J
 
involves: 129 * 129S/SvEv * C57BL/6J
 
Phenotypes:
Affected Systems
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behavior/neurological
increased susceptibility to pharmacologically induced seizures
behavioral despair
impaired coordination
increased locomotor activity
growth/size/body
increased body weight
homeostasis/metabolism
N
homeostasis/metabolism phenotype
N
increased gamma-aminobutyric acid level
increased glutamic acid level
increased glutamine level
increased isoleucine level
increased leucine level
increased valine level
nervous system
nervous system phenotype
N N
abnormal cerebral cortex morphology
abnormal dendrite morphology
abnormal nervous system physiology
increased susceptibility to pharmacologically induced seizures
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ttll7 Mutation:  40 strains or lines available
References
Original:  J:345300 Ping Y, et al., Tubulin Polyglutamylation by TTLL1 and TTLL7 Regulate Glutamate Concentration in the Mice Brain. Biomolecules. 2023 May 1;13(5)
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory

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