Ttll7^tm1Seto
Targeted Allele Detail

Summary

• Symbol: Ttll7^tm1Seto
• Name: tubulin tyrosine ligase-like family, member 7; targeted mutation 1, Mitsutoshi Setou
• MGI ID: MGI:6476783
• Synonyms: 7KO
• Gene: Ttll7 Location: Chr3:146558122-146689764 bp, + strand Genetic Position: Chr3, 72.28 cM, cytoband H3
• Alliance: Ttll7^tm1Seto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:345300
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a neo cassette. Exons 2 and 3 include initiation codons. ATGs were removed by homologous recombination. Immunoblot analysis with anti-TTLL7 antibodies confirmed the absence of protein expression in brain lysates from homozygous mutant mice. (J:345300)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ttll7 Mutation: 40 strains or lines available

References

• Original: J:345300 Ping Y, et al., Tubulin Polyglutamylation by TTLL1 and TTLL7 Regulate Glutamate Concentration in the Mice Brain. Biomolecules. 2023 May 1;13(5)
• All: 2 reference(s)