Fam3a^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fam3a^em1Cya
• Name: FAM3 metabolism regulating signaling molecule A; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6477316
• Synonyms: FAM3A^-, Fam3a^em1Cgen
• Gene: Fam3a Location: ChrX:73428325-73436878 bp, - strand Genetic Position: ChrX, 38.0 cM, cytoband A6
• Alliance: Fam3a^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A single-base deletion (T on coding strand, or A on forward strand) was engineered in exon 4 using TALENs. Western blot experiments confirmed the absence of protein expression from this allele. (J:295206)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fam3a Mutation: 7 strains or lines available

References

• Original: J:295206 Chen Z, et al., FAM3A mediates PPARgamma's protection in liver ischemia-reperfusion injury by activating Akt survival pathway and repressing inflammation and oxidative stress. Oncotarget. 2017 Jul 25;8(30):49882-49896
• All: 4 reference(s)