Fgfr2tm4.1Sor
Targeted Allele Detail
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Symbol: |
Fgfr2tm4.1Sor |
Name: |
fibroblast growth factor receptor 2; targeted mutation 4.1, Philippe Soriano |
MGI ID: |
MGI:6477570 |
Synonyms: |
Fgfr2C |
Gene: |
Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
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Alliance: |
Fgfr2tm4.1Sor page
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Germline Transmission: |
Earliest citation of germline transmission:
J:303230
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Parent Cell Line: |
AK7 (ES Cell)
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Strain of Origin: |
129S4/SvJaeSor
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Allele Type: |
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Targeted (Not Applicable) |
Mutation: |
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Nucleotide substitutions
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Mutation details: Site-directed mutagenesis was used to insert nucleotide substitutions in exon 11 of the locus, altering tyrosine to phenylalanine at codon 485 (Y485F-TAT to TTT) and a silent mutation, leucine to leucine at codon 487 (L487L -TTG to CTC) and introducing a Sac1 site. The substitutions were initially described as Y466F and L468L, respectively. In addition, a loxP and FRT-flanked neomycin-resistance gene was located downstream of exon 11. Flp-mediated recombination removed the FRT-flanked neo cassette.
(J:303230)
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Original: |
J:303230 Ray AT, et al., FGF signaling regulates development by processes beyond canonical pathways. Genes Dev. 2020 Dec 1;34(23-24):1735-1752 |
All: |
1 reference(s) |
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