Tspo2^em1Muti
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tspo2^em1Muti
• Name: translocator protein 2; endonuclease-mediated mutation 1, Mutsumi Inaba
• MGI ID: MGI:6478279
• Gene: Tspo2 Location: Chr17:48754935-48758550 bp, - strand Genetic Position: Chr17, 24.12 cM, cytoband C
• Alliance: Tspo2^em1Muti page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3 was targeted with an sgRNA (CTTTGTAGGTGTGCCC) and an ssODN (CTTTGTAGGTGTGCCCtaatagactagtctagCTGcag) using CRISPR/Cas9 technology, resulting in a 105 bp deletion. (J:292525)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tspo2 Mutation: 12 strains or lines available

References

• Original: J:292525 Kiatpakdee B, et al., Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts. J Biol Chem. 2020 Jun 5;295(23):8048-8063
• All: 1 reference(s)