Ins2^em#Arak
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ins2^em#Arak
• Name: insulin II; endonuclease-mediated mutation, Kimi Araki
• MGI ID: MGI:6478807
• Synonyms: Ins2^Q104del, Kuma
• Gene: Ins2 Location: Chr7:142232393-142233463 bp, - strand Genetic Position: Chr7, 88.0 cM
• Alliance: Ins2^em#Arak page

Mutation origin

• Strain of Origin: C.129-Rag2^tm1Fwa Jak3^tm1Tks/Arak

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 3 bp deletion, either CAG or AGC at c.310_312del or c.311-313 that results in a glutamine deletion at amino acid 104 (p.Q104del). (J:294041)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ins2 Mutation: 93 strains or lines available

References

• Original: J:294041 Sakano D, et al., Insulin2(Q104del) (Kuma) mutant mice develop diabetes with dominant inheritance. Sci Rep. 2020 Jul 22;10(1):12187
• All: 1 reference(s)