Mideas^em1Shmc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mideas^em1Shmc
• Name: mitotic deacetylase associated SANT domain protein; endonuclease-mediated mutation 1, Shaun M Cowley
• MGI ID: MGI:6479049
• Synonyms: MIDEAS-del1^-
• Gene: Mideas Location: Chr12:84195950-84265655 bp, - strand Genetic Position: Chr12, 39.07 cM
• Alliance: Mideas^em1Shmc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 sequence (TCCCTACTATAACCACCCGGAGG) was targeted with a crRNA using CRISPR/Cas9 technology, resulting in a 10 bp deletion. (J:291786)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mideas Mutation: 78 strains or lines available

References

• Original: J:291786 Turnbull RE, et al., The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure. Nat Commun. 2020 Jun 26;11(1):3252
• All: 1 reference(s)