Lnhrt^tm1.1Koho
Targeted Allele Detail

Summary

• Symbol: Lnhrt^tm1.1Koho
• Name: long intergenic RNA regulator of Myh6 in heart; targeted mutation 1.1, Koh Ono
• MGI ID: MGI:6480016
• Synonyms: Lionheart-KO
• Gene: Lnhrt Location: Chr2:77145095-77147379 bp Genetic Position: Chr2, Syntenic
• Alliance: Lnhrt^tm1.1Koho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:293789
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire 2-exon locus was replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination. (J:293789)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lnhrt Mutation: 0 strains or lines available

References

• Original: J:293789 Kuwabara Y, et al., Lionheart LincRNA alleviates cardiac systolic dysfunction under pressure overload. Commun Biol. 2020 Aug 13;3(1):434
• All: 1 reference(s)