Ppp1r14a^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ppp1r14a^em1Gpt
• Name: protein phosphatase 1, regulatory inhibitor subunit 14A; endonuclease-mediated mutation 1, Gempharmatech Co., Ltd
• MGI ID: MGI:6487902
• Synonyms: delta116
• Gene: Ppp1r14a Location: Chr7:28988732-28992817 bp, + strand Genetic Position: Chr7, 16.94 cM, cytoband A3
• Alliance: Ppp1r14a^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9-mediated recombination created a 116 bp deletion just downstream from the start site. Western blot analysis found nearly undetectable levels of protein in homozygous mice. (J:290992)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r14a Mutation: 15 strains or lines available

References

• Original: J:290992 Sun J, et al., CPI-17-mediated contraction of vascular smooth muscle is essential for the development of hypertension in obese mice. J Genet Genomics. 2019 Mar 20;46(3):109-118
• All: 1 reference(s)