Drc7^tm1.1Osb
Targeted Allele Detail

Summary

• Symbol: Drc7^tm1.1Osb
• Name: dynein regulatory complex subunit 7; targeted mutation 1.1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6488166
• Synonyms: Drc7^tm1.1Maik, Drc7^tm1b
• Gene: Drc7 Location: Chr8:95781731-95804769 bp, + strand Genetic Position: Chr8, 47.12 cM
• Alliance: Drc7^tm1.1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:284740
• Parent Cell Line: EGR-G101 (ES Cell)
• Strain of Origin: C57BL/6NSlc-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The KOMP targeting vector PG00082_Z_3_D01 was used to create an allele with an FRT site, lacZ gene, loxP site, neo cassette, FRT site, and loxP site upstream of exon 9 and a loxP site downstream of exon 11. Cre mediated recombination removed exons 9 11 and the neo cassette. Analysis of mRNA in testes from homozygous mice indicated absence of expression. (J:284740)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drc7 Mutation: 45 strains or lines available

References

• Original: J:284740 Morohoshi A, et al., Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice. PLoS Genet. 2020 Jan;16(1):e1008585
• All: 1 reference(s)