Fbxl13^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fbxl13^em1Osb
• Name: F-box and leucine-rich repeat protein 13; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6488167
• Synonyms: Fbxl13^em1Maik
• Gene: Fbxl13 Location: Chr5:21688845-21850632 bp, - strand Genetic Position: Chr5, 9.83 cM
• Alliance: Fbxl13^em1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:284740
• Parent Cell Line: EGR-G101 (ES Cell)
• Strain of Origin: C57BL/6NSlc-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination deleted a 30983 bp genomic region including exons 2-7. Analysis of mRNA in testes from homozygous mice indicated absence of expression. (J:284740)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fbxl13 Mutation: 46 strains or lines available

References

• Original: J:284740 Morohoshi A, et al., Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice. PLoS Genet. 2020 Jan;16(1):e1008585
• All: 1 reference(s)