Fbxw5^em1Syli
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fbxw5^em1Syli
• Name: F-box and WD-40 domain protein 5; endonuclease-mediated mutation 1, Shuyan Li
• MGI ID: MGI:6488664
• Gene: Fbxw5 Location: Chr2:25390762-25395482 bp, + strand Genetic Position: Chr2, 17.31 cM
• Alliance: Fbxw5^em1Syli page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 2 deleted 31 bp. (J:298305)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxw5 Mutation: 22 strains or lines available

References

• Original: J:298305 Hui X, et al., FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway. J Mol Cell Cardiol. 2020 Sep 22;151:31-43
• All: 1 reference(s)