Rrm2b^em1Mem
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rrm2b^em1Mem
• Name: ribonucleotide reductase M2 B (TP53 inducible); endonuclease-mediated mutation 1, Marcy E MacDonald
• MGI ID: MGI:6489292
• Synonyms: Rrm2b_del10
• Gene: Rrm2b Location: Chr15:37924196-37961562 bp, - strand Genetic Position: Chr15, 15.1 cM
• Alliance: Rrm2b^em1Mem page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted 10 bp. (J:298297)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rrm2b Mutation: 27 strains or lines available

References

• Original: J:298297 Loupe JM, et al., Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out. Hum Mol Genet. 2020 Nov 4;29(18):3044-3053
• All: 1 reference(s)