Fan1^em2Mem
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fan1^em2Mem
• Name: FANCD2/FANCI-associated nuclease 1; endonuclease-mediated mutation 2, Marcy E MacDonald
• MGI ID: MGI:6489296
• Synonyms: Fan1_ins1
• Gene: Fan1 Location: Chr7:63996506-64023843 bp, - strand Genetic Position: Chr7, 34.64 cM
• Alliance: Fan1^em2Mem page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• CRISPR-targeting inserted a single base pair. (J:298297)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fan1 Mutation: 99 strains or lines available

References

• Original: J:298297 Loupe JM, et al., Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out. Hum Mol Genet. 2020 Nov 4;29(18):3044-3053
• All: 1 reference(s)