Slco2b1tm1d(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Slco2b1tm1d(KOMP)Wtsi |
Name: |
solute carrier organic anion transporter family, member 2b1; targeted mutation 1d, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6489390 |
Synonyms: |
OATP2B1-, Oatp2b1-deficient |
Gene: |
Slco2b1 Location: Chr7:99307011-99360547 bp, - strand Genetic Position: Chr7, 54.11 cM
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Alliance: |
Slco2b1tm1d(KOMP)Wtsi page
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IMPC: |
Slco2b1 gene page |
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Mutant Cell Line: |
EPD0099_1_B03 |
Germline Transmission: |
Earliest citation of germline transmission:
J:287311
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 99337797 of Chromosome 7 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 99338675. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:287311)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Slco2b1 Mutation: |
36 strains or lines available
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Original: |
J:287311 Chen M, et al., Role of Oatp2b1 in Drug Absorption and Drug-Drug Interactions. Drug Metab Dispos. 2020 May;48(5):420-426 |
All: |
2 reference(s) |
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