Ano5^em1Huyi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ano5^em1Huyi
• Name: anoctamin 5; endonuclease-mediated mutation 1, Ying Hu
• MGI ID: MGI:6489964
• Synonyms: Ano5^-
• Gene: Ano5 Location: Chr7:51160777-51248457 bp, + strand Genetic Position: Chr7, 32.76 cM
• Alliance: Ano5^em1Huyi page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology created an 833 bp deletion encompassing exons 11 and 12 and generated a truncated transcript of 660 bp. (J:294237)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ano5 Mutation: 67 strains or lines available

References

• Original: J:294237 Wang X, et al., Genetic Disruption of Anoctamin 5 in Mice Replicates Human Gnathodiaphyseal Dysplasia (GDD). Calcif Tissue Int. 2019 Jun;104(6):679-689
• All: 1 reference(s)