Prdm9^em2Kpgn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Prdm9^em2Kpgn
• Name: PR domain containing 9; endonuclease-mediated mutation 2, Kenneth Paigen
• MGI ID: MGI:6489980
• Synonyms: Prdm9^EP
• Gene: Prdm9 Location: Chr17:15763341-15784616 bp, - strand Genetic Position: Chr17, 8.95 cM
• Alliance: Prdm9^em2Kpgn page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Nucleotide substitutions
• Mutation details: This catalytic hypomorph has a CRISPR/cas9-mediated GAG to CCG substitution resulting in a Glu360Pro (initially reported as 365) substitution in the PR/SET domain of C57BL/6J. (J:299008)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prdm9 Mutation: 46 strains or lines available

References

• Original: J:299008 Powers NR, et al., Sexual dimorphism in the meiotic requirement for PRDM9: A mammalian evolutionary safeguard. Sci Adv. 2020 Oct;6(43)
• All: 1 reference(s)