Marchf2^em1Cnu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Marchf2^em1Cnu
• Name: membrane associated ring-CH-type finger 2; endonuclease-mediated mutation 1, Chungnam National University
• MGI ID: MGI:6490470
• Gene: Marchf2 Location: Chr17:33904666-33937644 bp, - strand Genetic Position: Chr17, 17.98 cM
• Alliance: Marchf2^em1Cnu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 2 deleted 2bp (TG) altering the amino acid sequence (LCDCSSSPAFSKV to LLFEQP). (J:297482)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Marchf2 Mutation: 17 strains or lines available

References

• Original: J:297482 Chathuranga K, et al., Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2. EMBO J. 2020 Nov 2;39(21):e105139
• All: 1 reference(s)