N4bp1^tm1.2Vmd
Targeted Allele Detail

Summary

• Symbol: N4bp1^tm1.2Vmd
• Name: NEDD4 binding protein 1; targeted mutation 1.2, Vishva Dixit
• MGI ID: MGI:6490626
• Gene: N4bp1 Location: Chr8:87567764-87612489 bp, - strand Genetic Position: Chr8, 42.1 cM
• Alliance: N4bp1^tm1.2Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297419
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was flanked by loxP sites and F3/FRT sites. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2. (J:297419)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any N4bp1 Mutation: 46 strains or lines available

References

• Original: J:297419 Gitlin AD, et al., Integration of innate immune signalling by caspase-8 cleavage of N4BP1. Nature. 2020 Nov;587(7833):275-280
• All: 2 reference(s)