Coasy^tm1.1Vtr
Targeted Allele Detail

Summary

• Symbol: Coasy^tm1.1Vtr
• Name: Coenzyme A synthase; targeted mutation 1.1, Valeria Tiranti
• MGI ID: MGI:6491679
• Synonyms: Coasy^flox
• Gene: Coasy Location: Chr11:100973391-100977445 bp, + strand Genetic Position: Chr11, 64.17 cM, cytoband D
• Alliance: Coasy^tm1.1Vtr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:299154
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The ETPG00282_Y_2_E03 IMPC vector inserted an FRT site, lacZ reporer gene, loxP site, neomycin resistance cassette, FRT site, and loxP site upstream of exon 2. An additional loxP site was inserted downstream of the coding sequence in exon 9. Flp-mediated recombination removed the reporter/selection cassette and left exons 2 through 9 floxed. (J:299154)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Coasy Mutation: 15 strains or lines available

References

• Original: J:299154 Di Meo I, et al., Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model. Int J Mol Sci. 2020 Dec 19;21(24):9707
• All: 2 reference(s)