Tg(Or4e5-cre)1Hsak
Transgene Detail

Summary

• Symbol: Tg(Or4e5-cre)1Hsak
• Name: transgene insertion 1, Hitoshi Sakano
• MGI ID: MGI:6491953
• Synonyms: H-Cre, Olfr1507Cre, Tg-H-Cre, Tg(Olfr1507-cre)1Hsak
• Transgene: Tg(Or4e5-cre)1Hsak Location: unknown
• Alliance: Tg(Or4e5-cre)1Hsak page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Or4e5-cre)1Hsak expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Or4e5 (MGI:3031341)

• Mutation details: Cre recombinase gene is expressed under the control of upstream cis-acting DNA region of the mouse Olfr1507, 2-kb conserved homology region, mouse H element enhancer, which regulates odorant receptor (OR) gene cluster expression and Olfr1507 promoter. Due to the H enhancer activity, the Cre gene, now under the control of the Tg MOR28 promoter, is frequently chosen and activated for transcription in OSNs. The MOR28 promoter cannot be activated when any one of the endogenous OR genes is expressed first, due to OR-mediated negative feedback regulation. (J:167943)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Or4e5 (mouse) Summary of all recombinase alleles driven by Or4e5. Comparative matrix view of recombinase activities Alliance mouse Or4e5 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:167943 Takeuchi H, et al., Sequential arrival and graded secretion of Sema3F by olfactory neuron axons specify map topography at the bulb. Cell. 2010 Jun 11;141(6):1056-67
• All: 2 reference(s)