Card11^em1Welu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Card11^em1Welu
• Name: caspase recruitment domain family, member 11; endonuclease-mediated mutation 1, Wei Lu
• MGI ID: MGI:6491988
• Synonyms: E134G
• Gene: Card11 Location: Chr5:140858745-140986337 bp, - strand Genetic Position: Chr5, 79.42 cM
• Alliance: Card11^em1Welu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated an AG to GC change at position 401-402 resulting in a glutamate to glycine substitution at amino acid 134 (p.E134G) in exon 5. (J:292926)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Card11 Mutation: 59 strains or lines available

References

• Original: J:292926 Wei Z, et al., Pathogenic CARD11 mutations affect B cell development and differentiation through a noncanonical pathway. Sci Immunol. 2019 Nov 29;4(41)
• All: 1 reference(s)