Lrrc7^{Tg(Myl2-TSPYL)1Sich}
Transgenic Allele Detail

Summary

• Symbol: Lrrc7^{Tg(Myl2-TSPYL)1Sich}
• Name: leucine rich repeat containing 7; transgene insertion 1, Siu Yuen Chan
• MGI ID: MGI:6492209
• Gene: Lrrc7 Location: Chr3:157772823-158268254 bp, - strand Genetic Position: Chr3, Syntenic
• Alliance: Lrrc7^{Tg(Myl2-TSPYL)1Sich} page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Hypomorph, Inserted expressed sequence)
• Mutation: Insertion
• Lrrc7^{Tg(Myl2-TSPYL)1Sich} expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Myl2 (363925)

  Myl2	(MGI:97272)

• Mutation details: A single copy of a transgene consisting of the rat myosin light chain 2V promoter and the complete open reading frame of human TSPYL inserted at intron 1, disrupting transcription of Lrrc7 but not the nearby gene Lrrc40. Western blot analysis detected trace amount of protein in cerebral cortex of homozygous mice. Homozygotes express 2% of wild-type transcripts and heterozygotes express 46% of the normal amount of transcripts. (J:293568)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrc7 Mutation: 94 strains or lines available

References

• Original: J:293568 Chong CH, et al., Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulation. Transl Psychiatry. 2019 Oct 3;9(1):244
• All: 1 reference(s)