Matr3^em4Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Matr3^em4Tcp
• Name: matrin 3; endonuclease-mediated mutation 4, The Centre for Phenogenomics
• MGI ID: MGI:6500998
• Synonyms: em4 p.F115Lfs*7
• Gene: Matr3 Location: Chr18:35695191-35726888 bp, + strand Genetic Position: Chr18, 19.14 cM, cytoband C
• Alliance: Matr3^em4Tcp page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 4 bp deletion (TCTG) at phenylalanine 115 resulting in a frameshift and introducing a premature stop codon. (J:298091)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Matr3 Mutation: 112 strains or lines available

References

• Original: J:298091 Kao CS, et al., Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS. Nat Commun. 2020 Oct 20;11(1):5304
• All: 1 reference(s)