Gt(ROSA)26Sor^{tm8(CAG-dre/ERT2)Bzsh}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm8(CAG-dre/ERT2)Bzsh}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 8, Bin Zhou
• MGI ID: MGI:6501124
• Synonyms: R26-DreER
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm8(CAG-dre/ERT2)Bzsh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278026
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm8(CAG-dre/ERT2)Bzsh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: The targeting construct inserted into the locus via homologous recombination a cDNA encoding Dre recombinase fused with a mutant form of the estrogen receptor hormone-binding domain (ERT2). (J:278026)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	CAG (chicken) Summary of all recombinase alleles driven by CAG.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:278026 Li Y, et al., Genetic Lineage Tracing of Nonmyocyte Population by Dual Recombinases. Circulation. 2018 Aug 21;138(8):793-805
• All: 1 reference(s)