Cpa1^tm1Satom
Targeted Allele Detail

Summary

• Symbol: Cpa1^tm1Satom
• Name: carboxypeptidase A1, pancreatic; targeted mutation 1, Miklos Sahin-Toth
• MGI ID: MGI:6501752
• Gene: Cpa1 Location: Chr6:30639217-30645360 bp, + strand Genetic Position: Chr6, 12.52 cM, cytoband B1
• Alliance: Cpa1^tm1Satom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:300042
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 7 was replaced with a floxed neomycin resistance cassette and exon 7 mutated to produced the nucleotide substitution of asparagine with lysine at position 256 (N256K). The floxed neomycin resistance cassette prevents expression of either endogenous or mutated allele. (J:300042)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpa1 Mutation: 25 strains or lines available

References

• Original: J:300042 Hegyi E, et al., Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice. Gut. 2019;68(2):301-312
• All: 1 reference(s)