Cmtr1^{tm1b(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Cmtr1^{tm1b(EUCOMM)Hmgu}
• Name: cap methyltransferase 1; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6502647
• Synonyms: fCmtr1
• Gene: Cmtr1 Location: Chr17:29879569-29924953 bp, + strand Genetic Position: Chr17, 15.43 cM
• Alliance: Cmtr1^{tm1b(EUCOMM)Hmgu} page
• IMPC: Cmtr1 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:300305
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 29904379 of Chromosome 17 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 29905269. Exon 9 is thus flanked by loxP sites. The"conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying the knockout-first allele. (J:300305)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cmtr1 Mutation: 51 strains or lines available

References

• Original: J:300305 Lee YL, et al., CMTR1-Catalyzed 2'-O-Ribose Methylation Controls Neuronal Development by Regulating Camk2alpha Expression Independent of RIG-I Signaling. Cell Rep. 2020 Oct 20;33(3):108269
• All: 1 reference(s)